Bioinformatician

Position: Bioinformatician, Prostate Cancer
Site: MaRS Centre, Toronto
Department: Informatics & Bio-computing
Reports To: Principal Investigator
Salary: Commensurate with level of experience
Hours: 35 Hrs/week
Status: Temporary, Full-time (1-3 years)

Are you a guru in next-generation sequencing? Do you want to become one? The Ontario Institute for Cancer Research (OICR) is seeking a talented Bioinformatician to focus on the analysis of large next-generation sequencing datasets. We want somebody with an extensive interest in large-data problems and an in-depth knowledge of data-handling. But this position involves a very substantial analysis component and the successful applicant will be working closely with systems-administrators, statisticians, PhD students, and postdoctoral associates on:
• Optimization and parallelization of algorithms for the analysis of genome-sequencing data;
• Integration of diverse datasets into unified statistical models;
• Automating procedures for pipeline evaluation and assessment;
• Automation of routine programming and data-analysis tasks;
• Downstream data-modeling, including pathway analysis and clinical association studies.

The successful candidate will be working on the Canadian Prostate Cancer Genome Network (CPC-GENE), a project studying 500 prostate cancer patients. We are generating multiple independent genomic analyses, including mRNA and DNA microarrays, RNA-seq, whole genome-sequencing (PacBio and Illumina Hi-Seq), and some limited RNAi functional screen data. Rich clinical annotation is also available on these samples, and analyses are performed on cutting-edge IT infrastructure including a multi-petabyte storage system and a >6,500-core compute farm.

QUALIFICATIONS
• B.Sc. or equivalent education in computational biology, engineering, mathematics, computer sciences or molecular biology;
• Strong background with unix/linux tools and administration required;
• Experience in software and database programming (R, Perl, SQL);
• Exposure to next-generation sequencing data;
• Statistical background in machine-learning, survival or Bayesian techniques is a major asset;
• Knowledge of molecular and/or cancer biology beneficial;
• Proven experience with bioinformatics resources and/or databases is an asset;
• Experience working with test-driven programming and version control is an asset.

OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Economic Development and Innovation.

For more information about OICR, please visit the website at www.oicr.on.ca.

POSTED DATE: February 1, 2012
CLOSING DATE: March 1, 2012

Interested candidates may apply here
https://www.recruitingsite.com/csbsites/oicr/JobDescription.asp?JobNumbe...

OICR has a diverse workforce and is an equal opportunity employer.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted. Candidates will be expected to provide their current employer as a reference.

Resume Format: If you elect to apply, you will need a text or HTML version of your resume so that you can cut and paste it into the application box provided. Before you submit the completed application, you will be asked to attach one or two files to your application. Please attach your resume as a .doc file.