Links tagged with 'g-protein-coupled receptors'

GPCRDB

http://www.gpcr.org/7tm/

The GPCRDB is a Molecular Class-Specific Information System (MCSIS) that collects, combines, validates and disseminates large amounts of heterogeneous data on G protein-coupled receptors (GPCRs). The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data such as multiple sequence alignments and homology models. The GPCRDB provides access to the data via a number of different access methods. It offers visualization and analysis tools, and a number of query systems. The data is updated automatically on a monthly basis.

NAR Database Issue 2011

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tagsg-protein-coupled receptors ligands mutation protein databases protein sequence analysis protein structural homology sequence alignment

IUPHAR-DB

http://www.iuphar-db.org

The IUPHAR database is an online reference resource for classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database now includes information from four superfamilies in human and rodent model organisms: G protein-coupled receptors, voltage- and ligand-gated ion channels and nuclear hormone receptors (NHRs). New data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures. The interface provides tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target.

NAR Database Issue 2011

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tagsanimals cytoplasmic and nuclear receptors g-protein-coupled receptors humans ion channels ligands pharmaceutical preparations protein databases

SuperSweet

http://bioinformatics.charite.de/sweet/

SuperSweet is a collection of carbohydrates, artificial sweeteners and other sweet tasting agents like proteins and peptides. Structural information and properties such as number of calories, therapeutic annotations and a sweetness-index are stored in SuperSweet. The database provides a modeled 3D structure of the sweet taste receptor and binding poses of the small sweet molecules. A user-friendly graphical interface allows similarity searching, visualization of docked sweeteners into the receptor etc. A sweetener classification tree and browsing features allow quick requests to be made to the database.

This content is being maintained by robertpreissner.

NAR Database Issue 2011

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tagsamino acids binding sites carbohydrates factual databases g-protein-coupled receptors protein structural homology proteins sweetening agents